Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 9th International Conference on Biopolymers and Polymer Sciences Bucharest, Romania.

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Scientific Program Day 1
Scientific Program Day 2

Day 2 :

Keynote Forum

Benny Danilo Belviso

Institute of Crystallography (CNR), Italy

Keynote: Advanced materials to make easier protein crystallization

Time : 10:00-10:45

Conference Series BiopolySci 2018 International Conference Keynote Speaker Benny Danilo Belviso photo
Biography:

Benny Danilo Belviso has completed his PhD from University of Bari Aldo Moro and Postdoctoral studies from Institute of Crystallography (CNR). He has worked at Nottingham University in the MRC project to study ADAMTS13 protein structure and currently he is the Research Fellow at Institute of Crystallography. He is involved in several international projects related to structural biology and materials for crystallization applications. He has published more than 20 papers in reputed journals.
 

Abstract:

Since 60 years, X-ray crystallography provides structural details of protein molecules, information that is crucial to unravel biological mechanisms at molecular level. Crystallography requires that sample is in crystal form. Getting such crystals at acceptable quality for crystallographic analysis is not trivial and strategies to make this process less expensive and time consuming are not available, still now. Advanced materials represent a turning point in this field because they can be exploited to control nucleation and growth step, making more effective the crystallization process. Our group is developing membranebased materials able to trigger protein crystallization also in conditions that are not fruitful by standard methods. Such materials have a great impact both in industry and academic studies because significantly reduce cost and time of the protein purification and crystallization process. We developed membrane-materials functionalized by hydrogel that proved ability in getting very stress-resistant crystals, which are suitable for structure-based drug design studies that require very harsh soaking conditions. This material, similarly to our metal oxide nanoparticle-functionalized membrane, significantly widens crystallization window and produce crystals having good diffraction quality. Membrane based materials are showing very effective in protein crystallization and to produce crystals having specific features. Our efforts are focusing now in functionalizing such materials by nanotemplate to crystallize very challenging proteins such as intact antibodies, and to develop membrane able to promote bio-mineralization and to enable polymorphs selection.
 

Break: 10:45-11:00

Keynote Forum

Ramin Zibaseresht

Maritime University of Imam Khomeini, Iran

Keynote: Synthesis, structural analysis and antibacterial effect of a novel heteronuclear Ag(I)-Fe(II) coordination polymer

Time : 11:00-11:45

Conference Series BiopolySci 2018 International Conference Keynote Speaker Ramin Zibaseresht photo
Biography:

Ramin Zibaseresht is a Professor in Chemistry at Maritime University of Imam Khomeini in Noshahr and Adjunct Professor at Aja University of Medical Sciences in Tehran. He has completed his BSc in Chemistry from Shiraz University and his MSc in Inorganic Chemistry from Pune University. He has completed his PhD in Inorganic Chemistry from the University of Canterbury. He is currently the Head of Biomaterials and Medicinal Chemistry Research Centre in Tehran. He has published more than 50 papers in reputed journals and some international conferences and more than 10 books in the area of chemistry and 4 patents. He has been serving as an Editorial Board Member of some peer-reviewed journals, academic book publishers, member of more than 10 academic committees, organizing committees and academic boards of international conferences.
 

Abstract:

The synthesis and crystal structure of a novel polymeric silver(I)-iron(II) complex containing bridging ligand 4’-(4-(2,2,2-tris(1H-pyrazol-1-ido)ethoxymethyl)phenyl-2,2’:6’,2”-terpyridine (TPT) are described. The reaction of TPT with FeCl2.6H2O afforded a complex [Fe(TPT)2]Cl2 which in turn reacted with a range of silver salts such as AgNO3, AgClO4 resulted in the formation of hetero-metal complexes which were characterized using 1H NMR and ES-MS techniques. The reaction solution of the [Fe(TPT)2]Cl2 complex with molar equivalent of AgClO4 resulted in a solution with face needlelike crystals suitable for single X-ray crystallography. The complex was crystallized the triclinic space group, PÄ«. The smallest repeating unit of the complex contains an [Fe(TPT)Ag2(H2O)2](ClO4)3 unit. The Fe atom is coordinated by three nitrogen of terpyridine moiety from one TPT ligand and by three nitrogen of terpyridine moiety from another TPT ligand in an octahedral geometry fashion. While one Ag atom is coordinated by two nitrogen atoms of one pyrazolyl moiety from a TPT ligand and two nitrogen atoms of adjacent pyrazolyl moiety from another TPT ligand to generate a linear coordination polymer in a tetragedral geometry. The third nitrogen atom of the last pyrazolyl part is also coordinated to a silver ion which was itself coordinated to two water molecules through their oxygen atoms in a trigonal planar geometry. The shortest Ag-Ag distance is 5.337(1) Å within a TPT ligand. The Fe-Ag distances are 10.480(1) Å, 15.0637(1) Å within a unit cell. In vitro the study of the complex against some bacterial pathogens were also investigated.
 

  • Crystallography of Novel Materials | Chemical Crystallography | Role of Polymers in Biological Systems | Recent Development in the X-ray Studies | Biodegradable Polymers | Biomaterials and Biopolymers
Location: Bucharest, Romania
Speaker

Chair

Nimrod Israely

Biofeed Environmentally Friendly Pest Control, Israel

Speaker

Co-Chair

Tasnim Kossentini Kallel

National School of Engineers of Sfax, Tunisia

Session Introduction

Nikolay PLUSNIN

FEB RAS-Institute of Automation and Control Processes, Russia

Title: Conjoint AES - EELS analysis of the subnanometric coatings

Time : 11:45-12:15

Speaker
Biography:

Nikolay Plusnin is currently working as the Chief Researcher in the Institute of Automation and Control Processes of FEB of the RAS, Vladivostok, Russia. He has completed the studies as Doctor of Physical-Mathematical Sciences. His research interests are in nanomaterials for electronics and their structure-phase analysis. He was a Visiting Professor in Tohoku University, Sendai, Japan. He is also a Member of the Advisory Board of the International journal, e-journal of Surface Science and Nanotechnology. He has published more than 35 scientific articles. His research was supported by Russian Ministry of Education and Science, Academy of Sciences and Government.
 

Abstract:

The purpose of the work is to show possibilities of a joint electron spectroscopy of Auger Electrons (AES) and of energy losses on valence electrons (EEES) for analysis of the structural-chemical and phase state of 2D or sub-nanometric coatings. The composition, thickness, growth mechanism and electronic energy structure of coatings were determined according to the AES data. In addition, the structural-phase state and the local electronic spatial structure of the coating were determined according to the EELS data. The choice of the optimal probing depth (0.25 nm) has been ensured the mutual additivity of analysis by two methods and its adaptation to the sub-nanometric thickness of coatings. It is shown that EELS is very sensitive method for analysis of local valence electron density of atoms and that the variation of the energy of the primary beam and of parameters the coating (the thickness of the coating, the arrangement of adatoms-markers, the coating deposition regimes), as well as the subtraction of the contribution from the substrate, make possible to increase informativity of the AES-EELS analysis of subnanometric coatings and structural state of their interface.
 

Bakti Berlyanto Sedayu

Victoria University, Australia

Title: Effects of glycerol incorporation on Semi-Refined Carrageenan film properties

Time : 12:15-12:45

Speaker
Biography:

Bakti B Sedayu is undertaking PhD research program in Victoria University, Australia. His project focuses on development of packaging material from seaweed.

Abstract:

Derived from renewable, abundant seaweed, carrageenan-based films are becoming popular as food packaging material. In this work, semi-refined carrageenan (SRC) plasticized with glycerol were developed and characterised. The mechanical strength, moisture content, and optical properties of the films generally increased significantly with increasing glycerol concentration, however, the water vapor permeability decreased. In particular, the tensile strength and elongation at break increased at plasticizer additions of up to 40% and 50% (w/w) respectively. The addition of glycerol also improved the thermal stability and surface morphology of the films. The results show that the properties of the SRC films were comparable with refined carrageenan films suggesting that SRC has potential to be furthered developed into less expensive food packaging materials.
 

Break: 12:45-13:45

Delia-Laura Popescu

University of Bucharest, Romania

Title: Structural properties and topological diversity of new ORGANOTIN(IV) cordination compounds

Time : 13:45-14:15

Speaker
Biography:

Delia-Laura Popescu has completed her BS in Chemistry from Faculty of Chemistry, University of Bucharest. She has competed both MS and PhD degrees from the Carnegie Mellon University, Pittsburgh, USA, under the guidance of Professor Terrence J Collins having worked in green chemistry field. She was a Postdoctoral Researcher in Professor Nicolay Tsarevsky’s group in the Department of Chemistry at Southern Methodist University, Dallas, USA. She is currently an Assistant Professor in the Department of Inorganic Chemistry at Faculty of Chemistry, University of Bucharest. Her research interests include porous materials (MOFs), supra-molecular hybrid metal-organic materials, poly-nuclear coordination systems with biological properties.
 

Abstract:

Organotin(IV) coordination compounds have been the subject of interest for some time due to their properties, structural aspects and potential biomedical, environmental and commercial applications. A new series of coordination compounds with different organotin(IV) subunits as nodes and organic bridging ligands as spacers were prepared. The combination of organotin(IV) building blocks with O- and N-donor ligands resulted in the formation of new extended structures with 0D, 1D (an example is given in figure-1), 2D and 3D dimensionalities and interesting topologies. The influence of the nature of organotin(IV) nodes and the bridging ligands on the structural properties of the new systems obtained was investigated. All the synthesized compounds have been characterized by elemental analysis, standard spectroscopic techniques (FTIR, UV-Vis-NIR, NMR), thermal analysis, as well as by single crystal and powder X-ray diffraction. The ligands, metal precursors and their corresponding organotin(IV) complexes have also been screened for antimicrobial activities.

Tasnim Kossentini Kallel

National School of Engineers of Sfax, Tunisia

Title: Assessment of biodegradation and biological properties of modified biopolymers

Time : 14:15-14:45

Speaker
Biography:

Tasnim Kossentini Kallel is an associate professor in the Materials Engineering Department in the National School of Engineers of Sfax (Sfax University; Tunisia). In 1998-1999 she was Senior Safety Engineer at the Association of Health and Security at Work of Sfax "ASSETS" and in 2000-2003 she was a Researcher Member in the Laboratory of Macromolecular Materials INSA Lyon: Institute National des Sciences Appliqués de Lyon (France). In the Laboratory of Advanced Materials, she currently supervises a research team investigating the areas of advanced polymer blends and composite materials. She has been interested in various research areas including, polymer blends and composites designed for recycling, processing control of nano-composites and bio-composites via solvent casting method and reactive extrusion. She has planned, managed and completed projects under collaboration agreements with several foreign laboratories and industrial businesses. She has published a patent and 27 research articles.
 

Abstract:

There has been a growing interest over the past few years in the development of biopolymers partly because of their renewable, sustainable and biodegradable properties. They generally display interesting properties such as biodegradability, biocompatibility and their generated products are not toxic. Therefore, they possess various biological activities such as antibacterial, antioxidant and antifungal activities. These advantages, in parallel with the recent technological developments in biopolymer production, have rapidly expanded their applications as a competitive commodity polymer in a variety of processes. However, because of their inherent brittle nature, biopolymers generally need to be modified to be suitable for use in various applications where mechanical properties are important. So it is very interesting to toughen them with the goal of balancing and increasing tensile strength, impact strength and modulus while retaining the biocompatible and biodegradable nature of the polymer. The study concentrates on the biological activity and biodegradation capability of biopolymer blends in the solid state and in the liquid phase under aerobic and anaerobic conditions. To this end, blends were processed by casting method and on a twin-screw extruder with a film die and to determine the efficiency of the biodegradation of polymers, quantitative (mass variations, BOD) and qualitative (DSC and SEM) analyses were made. Otherwise, biopolymers were evaluated for their biological, structural and thermal properties.
 

Ramin Zibaseresht

Maritime University of Imam Khomeini, Iran

Title: Synthesis, structural analysis and DNA interaction of Bis[4'-(4-methylphenyl)-2,2':6',2

Time : 14:45-15:15

Speaker
Biography:

Ramin Zibaseresht is a Professor in Chemistry at Maritime University of Imam Khomeini in Noshahr and Adjunct Professor at Aja University of Medical Sciences in Tehran. He has completed his BSc in Chemistry from Shiraz University and his MSc in Inorganic Chemistry from Pune University. He has completed his PhD in Inorganic Chemistry from the University of Canterbury. He is currently the Head of Biomaterials and Medicinal Chemistry Research Centre in Tehran. He has published more than 50 papers in reputed journals and some international conferences and more than 10 books in the area of chemistry and 4 patents. He has been serving as an Editorial Board Member of some peer-reviewed journals, academic book publishers, member of more than 10 academic committees, organizing committees and academic boards of international conferences.
 

Abstract:

There has been extensive studies of binding of chiral Ru(II) complexes to DNA backbone structures. J K Barton has studied the cationic coordination of a variety of chiral poly-pyridine Ru(II) complexes to demonstrate chiral discrimination in binding to different forms of DNA. Many experimental techniques have been applied to study the interaction of tris(phenanthroline) ruthenium(II) ([Ru(phen)3]2+) with DNA, but despite this, its binding mode and its effect on the DNA structure are uncertain and have been the subject of much controversy. In this study, bis[4’-(4-methylphenyl)-2,2’:6’,2’’-terpyridine]Co(III) tris(nitrate) complex was synthesized and characterized using conventional method such as 1H NMR, ES-MS, UV-vis spectrophotometry. The crystal structure of the complex was also determined. The complex was crystallized in the triclinic space group, PÄ« with two well separated complex molecules in the unit cell along with four hydrogen bounded water molecules and six nitrate groups. The Co ion was six coordinated, but the geometry was significantly distorted from that of an ideal octahedral. In this study, the terpyridine type ligand fragment appealed because the ligand structure ensures a meridional arrangement of the donor atoms, which reduces the number of possible isomers. Co(III) ion was attracted because of its higher positive charge compared to Ru(II) which will have more affinity towards the negatively charged DNA structure. Absorbance and fluorescence methods and circular dichroism were used to study the interaction of the Co(III) complex solution in water with DNA.
 

Francisco Fábio Oliveira de Sousa

Federal University of Amapa School of Pharmacy, Brazil

Title: Biopharmaceutical and functional activities improvement by drug-biopolymers association

Time : 15:15-15:45

Speaker
Biography:

Francisco Fabio Oliveira de Sousa has completed his PhD from University of Santiago de Compostela, Spain and Postdoctoral studies from Federal University of Ceara School of Dentistry, Brazil. He is the Director of Experimental and Clinical Pharmacy research group with 9 PhD and undergraduate students, coordinating different projects in pharmaceutical technology and biomaterials. He has published more than 10 papers in reputed journals and has been serving as an Editorial Board Member for many journals. In 2018, he has been awarded the Scientific Yearly Prize by the Brazilian Council Research.
 

Abstract:

Zein is a biodegradable protein found in the maize endosperm (Zea mays). In the pharmaceutical industry, it has been used as a coating agent in solid forms and in the composition of drug delivery systems, where it has shown the ability to entrap drugs, lipids and genetic material, promoting their controlled release. Its biological potential has gained attention lately. Thus, the antioxidant and antimicrobial activities of zein solely have been identified, but barely explored. The associations of biopolymers to drugs could result in synergistic or additive effects, depending on the structure, solubility, partition coefficient and chemical interactions to the other compounds, resulting in new outcomes. In view of the biological properties of zein, we assessed the improvement in the antimicrobial and antioxidant activities of this biopolymer when associated to some phenolic bioactive, such as Ellagic Acid (EA). Their chemical association was accessed by 1H saturation Transfer-Difference Nuclear Magnetic Resonance (STD-NMR) to explain these outcomes. The micro dilution method was used to assess the minimum inhibitory and bactericide concentrations. The antioxidant activity was determined using the 2, 2-diphenyl-1-picryl-hydrazila free radical scavenging method. EA has shown inhibitory activity against Staphylococcus aureus and Pseudomonas aeruginosa and an antioxidant IC50 of 0.079 mg/mL. Zein has shown antimicrobial and antioxidant activities itself and enhanced synergically the antioxidant and the antimicrobial activity against P. aeruginosa when combined with EA. 1H STD-NMR experiment confirmed the formation of a complex between EA and zein that could be related with the improvement on its biological performance over the individual compounds. 

Break: 15:45-16:00

Denis Mihaela Panaitescu

National Institute for Research & Development in Chemistry and Petrochemistry – ICECHIM, Romania

Title: Porous structures from nanocellulose and biopolymers for biomedical application

Time : 16:00-16:20

Speaker
Biography:

Denis Mihaela Panaitescu has completed her PhD from University Politehnica of Bucharest, Romania. She is a Senior Researcher at ICECHIM. She has published more than 70 papers in reputed journals and has managed several national projects.
 

Abstract:

Bacterial cellulose has attracted a lot of interest in the last years due to its extraordinary properties for biomedical applications, high purity, water-uptake capability, good biocompatibility, cell adhesion, proliferation, good mechanical properties and non-toxicity of itself and its degradation products. A key element in tissue engineering is the 3D biomaterial scaffold which mimics the architecture of the Extra Cellular Matrix (ECM). ECM provides structural support for cell attachment, proliferation and differentiation. For this purpose, the 3D scaffolds should possess a network of interconnected pores ensuring cell migration, diffusion of nutrients and clearance of wastes and promoting cell adhesion and cell growth. More than 80% porosity is requested for porous scaffolds to mimic native ECM. Many tissues like heart, cartilages or bones have a fiber-sponge complex architecture and the nanofibrillated network of bacterial cellulose is similar to native ECM as respects biocompatibility, fibers size and assembling. However, the pore size of the cellulose network is much too low than the recommended minimum pore size of 100 microns, which limits cell penetration and migration. Hear we propose new methods to obtain porous biocomposite scaffolds using bacterial cellulose and eco-friendly additives and processes. Bacterial cellulose was modified with different agents and crosslinkers and the properties of the new porous structures were investigated by thermogravimetric analysis, atomic force microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy and dynamic mechanical analysis. This study has shown that highly porous cellulose structures that combine lightweight and stiffness may be obtained by using simple and eco-friendly methods.
 

Ioana Chiulan

The National Institute for Research & Development in Chemistry and Petrochemistry ICECHIM, Romania

Title: Influence of nanosilica content on the thermal and mechanical properties of liquid silicone elastomers

Time : 16:00-16:20

Speaker
Biography:

Ioana Chiulan has completed his PhD in 2011, from University Politehnica of Bucharest, in the field of thermoresponsive hydrogels. He has an experience of more than 10 years as researcher and her work is focused on different materials for biomedical or packaging applications. He is co-author in more than 19 papers and one book chapter. Raluca Gabor, Cristian Nicolae, Denis Panaitescu and Adriana Frone are highly skilled researchers, specialized in thermal, mechanical and morphological characterization. Elena Radu and Sergiu Stoian are recently graduated students from University Politehnica of Bucharest

Abstract:

Silicone rubbers are one of the most important polymers, because they possess important properties, such as biocompatibility, large degree of flexibility, hydrophobicity, high gas permeability, high thermal stability, good UV and oxidative resistance. However, pure silicone rubber has poor tensile strength, which limits its practical applications. To overcome this drawback, different inorganic fillers were incorporated such as nano-SiO2, carbon nanotube, nano-Al2O3, clay and so on. The aim of this work was to obtain composites based on liquid silicone rubber and hydrophilic nanosilica (HDK N20), with good flexibility and tensile strength, as potential biomaterials for pelvic prosthesis. Nanosilica particles were selected as reinforcing filler due its extraordinary properties, such as a very high specific surface area, biocompatibility, high elastic modulus, low density and low material cost. This paper reports the impact of the filler content and sample thickness on the morphology, rheological properties, thermal behavior and tensile strengths before and after flexing tests of the silicone-nanosilica composites. The addition of the nanosilica content up to 3% conducted to a significant increase of the young modulus and the tensile strength.